risk of mutation:

This risk calculation formula allows clinicians to explore the change in risk probability for patients with different combinations of clinical risk factors. The manuscript detailing the development and validation of this model will be published in the near future.

Using the risk score calculation together with an individual’s specific circumstances could help to prioritize the most urgent patients for hereditary counselling and testing. However, this resource is not meant to guide or advise individual patients. Although we validated the model internally, external validation is necessary. This should not be interpreted as medical advice or replace the expert opinion of a medical doctor.

*Family History Criteria Defined As: Any family history of prostate, breast, ovarian, or pancreatic cancer in a primary relative.

Yip SM, Sunderland K, Beigi A, Angeles A, Khalaf D, Warner E, Vandekerkhove G, Sun S, Annala M, Wyatt AW, Chi KN. Predictors of germline DNA damage repair gene mutations (gDDRm) in patients (pts) with metastatic castration-resistant prostate cancer (CRPC). J Clin Oncol. 2019; 37: Abstr 159.